I've been on the HU since January. I will never forget how difficult it was to swallow that first capsule. It is just something no one ever wants to start putting in their body. I have had very little side affects. Early on, I was tired. But now I have no affects from it. My platelets moved down quite abit on 500 mgs a day...but not enough. I now take 500 four days a week and 1000 three days a week. I get bloodwork tomorrow to see if this amount is still adequate.

Good news, Sammy!