Now been on Hydrea for almost a month...my last visit went very well Platelets went from 1034 to 784! (in 11 days!) I go back 6-22 for another blood count, been lucky no side effects except at first I tired more easily (this has slowly gotten better) Dr. will let me quit taking HU when count gets to 600...so I'm optimistic that they will continue to drop...Mimi (in NC)